Hung Yi Che is a physician in the Department of Chinese Medicine at Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan. His clinical and academic interests focus on Traditional Chinese Medicine and integrative approaches to chronic disease. He is particularly interested in the gut kidney brain axis and its potential links to depressive symptoms in patients with chronic kidney disease. His research interests include gut microbiota, uremic metabolites, neuroimmune signaling, and interactions between physical and psychological health. He aims to bridge traditional Chinese medicine with contemporary biomedical research to explore evidence-based, patient centered approaches to improving physical and psychological well being.